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crossnma:一个R包,通过网络元分析和网络元回归来综合交叉设计证据和交叉格式数据
Tasnim Hamza1,2, Guido Schwarzer3, Georgia Salanti4
1Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. tasnim.hamza@unibe.ch.
BMC medical research methodology
|August 5, 2024
概括
该R包crossnma集成了来自随机临床试验 (RCT) 和非随机研究 (NRS) 的个人参与者数据 (IPD) 和汇总数据 (AD),用于强大的网络元分析 (NMA) 和网络元回归 (NMR). 这有助于综合综合综合的证据.
科学领域:
- 生物统计学 生物统计学
- 卫生经济学 卫生经济学
- 临床流行病学临床流行病学
背景情况:
- 网络元分析 (NMA) 通常使用来自随机临床试验 (RCT) 的汇总数据 (AD).
- 非随机研究 (NRS) 和个人参与者数据 (IPD) 提供了有价值的见解,但在NMA中未得到充分利用.
- IPD允许更好地调整参与者特征,处理异质性和不一致性.
研究的目的:
- 为交叉格式 (IPD和AD) 和交叉设计 (RCT和NRS) 的网络元分析 (NMA) 和网络元回归 (NMR) 引入R包crossnma.
- 为在网络元分析中整合各种数据类型提供一个用户友好的工具.
主要方法:
- 研发R套餐的跨度数量.
- 使用Just Another Gibbs Sampler (JAGS) 实现贝叶斯三级层次模型.
- 包括用于自动创建JAGS模型,重新格式化数据,融合评估和结果总结的功能.
主要成果:
- 交叉nma包成功执行交叉格式和交叉设计NMA和NMR.
- 使用六项试验网络,比较四种治疗方法,展示了工作流程.
- 该方案促进了所有类型的证据的整合,承认了各种偏见风险.
结论:
- 该R包crossnma使贝叶斯的NMA和NMR能够使用各种数据类型.
- 方便将所有可用的证据纳入网络元分析.
- 通过适应不同的研究设计和数据格式来改善证据的综合.
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