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Updated: Jun 17, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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在BRCA1二次拼接部位的突变驱动了表突跳转和PARP抑制剂耐药性

Ksenija Nesic1,2, John J Krais3,4, Yifan Wang3

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Molecular cancer
|August 5, 2024
PubMed
概括

卵巢癌中PARP抑制剂耐药性可以通过BRCA1外因突破发生,由二次拼接位突变驱动. 监测这些突变为克服治疗耐药性的新策略提供了机会.

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