相关实验视频

Updated: May 5, 2026

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

稳定脂质体的弹性对它们的体内行为没有影响

Alicja Hinz¹, Joanna Lewandowska-Łańcucka², Ewa Werner³

¹Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Kraków, 30-387, Poland.

Journal of nanobiotechnology

|August 5, 2024

概括

用网络修改脂质体 (LIP-SS) 并没有提高它们的体内性能或瘤保留. 修改后和未修改后的脂质体都观察到免疫反应的激活,这表明需要进一步的表面修改.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

纳米载体的弹性机械性质对于有效的治疗提供至关重要.
脂质体弹性可以影响体内稳定性,细胞相互作用和细胞吸收.
网络的整合旨在增强脂质体弹性机械性质.

研究的目的:

分析修饰脂质体 (LIP-SS) 的体内行为.
在乳腺癌小鼠模型中评估药理动力学概况,生物分布和瘤保留.
在健康小鼠中评估改性脂质体的生物相容性.

主要方法:

脂质体 (LIP-SS) 用内部网进行了修改.
在体内研究涉及小鼠的药物动力学概况,生物分布和瘤保留分析.
生物相容性通过血液形态学和器官功能测试,以及细胞因子水平测量来评估.

主要成果:

与对照脂质体 (LIP-CAT) 相比,改造 (LIP-SS) 并没有改善药理动力学概况,生物分布或瘤保留.
生物相容性研究显示,对血液,肝脏,脏或功能没有不良影响.
所有测试的脂质体都诱导了长时间的免疫反应,由增加的促炎细胞因子证明.

结论:

内部网的修改并没有改变体内脂肪体的特性.
建议使用隐形聚合物进行表面功能化,以改善药理动力学和瘤向.
脂质体诱导的免疫激活和细胞因子生产背后的机制需要进一步研究.

关键词:

脂质体是一种脂质体.纳米载体弹性纳米载体弹性纳米粒子生物分布纳米粒子生物分布纳米粒子瘤积累纳米粒子瘤积累纳米毒性纳米毒性有关炎症的细胞因子.网是一种网.

更多相关视频

Stiffness Measurement of Soft Silicone Substrates for Mechanobiology Studies Using a Widefield Fluorescence Microscope

Stiffness Measurement of Soft Silicone Substrates for Mechanobiology Studies Using a Widefield Fluorescence Microscope

Published on: July 3, 2018

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Published on: July 30, 2020

相关概念视频

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...