威尔姆斯瘤的生存特征,这是从纵向队列研究中开发的参考
Anas Elgenidy1, Ahmed M Afifi2, Eman F Gad3
1Faculty of Medicine, Cairo University, Cairo, Egypt.
Italian journal of pediatrics
|August 5, 2024
概括
威尔姆斯瘤的存活率受到年龄和瘤扩散的影响,年轻的患者和局部瘤显示出更好的结果. 晚期和区域性传播显著恶化了生存率,突出了对量身定制治疗的需求.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症流行病学 癌症流行病学
- 临床病理学 临床病理学
背景情况:
- 威尔姆斯瘤 (WT) 存活率表现出因不断演变的临床和生物预后因素所影响的差异.
- 进一步的研究对于解决和减少WT患者的生存率差异至关重要.
研究的目的:
- 评估临床病理学数据对威尔姆斯瘤患者生存结果的影响.
- 确定影响WT癌症特异性生存率 (CSS) 的关键预后因素.
主要方法:
- 使用SEERStat数据库 (8.3.9.2版本) 来提取威尔姆斯瘤患者数据.
- 应用国际瘤分类 (ICDO-3) 患者选择的代码,不包括不完整的数据.
- 进行了统计分析,包括Kaplan-Meier估计和Cox回归模型 (R软件版本3.5).
主要成果:
- 总体而言,五年生存率为93.6%,十年生存率为92.5%.
- 远距离传播 (aHR 9.22),区域传播 (aHR 2.84),未知阶段 (aHR 4.98) 与更糟糕的CSS有显著的关联.
- 年龄较小 (<3岁) 在单变量分析中显示出优异的CSS (cHR 0.48),但在多变量模型中并不显著.
结论:
- 临床病理学变量显著影响威尔姆斯瘤生存动态.
- 个性化干预对于改善生存率至关重要,通过解决年龄,阶段和瘤扩散的问题来提高生存率.
- 持续的研究对于完善治疗策略和减少WT患者治疗结果的差异至关重要.
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