对BCG不响应的非肌肉侵入性膀癌的保守治疗的发展
Daniele Dutto1, Simone Livoti1, Francesco Soria1
1Division of Urology, Department of Surgical Sciences, San Giovanni Battista Hospital, University of Studies of Torino, Turin, Italy.
Expert opinion on pharmacotherapy
|August 6, 2024
概括
对于对Bacillus Calmette-Guerin (BCG) 治疗无反应的非肌肉侵入性膀癌 (NMIBCs),膀保护策略至关重要. 研究探索当前和未来的疗法,以避免激进囊切除.
科学领域:
- 尿瘤学 尿瘤学
- 膀癌治疗方法 膀癌治疗方法
- 免疫治疗是一种免疫疗法.
背景情况:
- Calmette-Guerin (BCG) 是中等/高风险的非肌肉侵入性膀癌 (NMIBCs) 的标准.
- 高达50%的NMIBC患者复发,20%的患者进展为肌肉侵入性膀癌 (MIBC).
- 激进囊切除术 (RC) 是有效的,但病态的,促使人们需要节省膀的替代品.
研究的目的:
- 审查BCG不响应的NMIBC的膀保护策略.
- 涵盖过去,现在和未来的治疗选择.
主要方法:
- 对BCG不响应的NMIBC进行膀保护治疗的文献综述.
- 对静脉内化学疗法,全身免疫疗法和新药的分析.
主要成果:
- 肠道灌注和全身免疫疗法显示短期有效性.
- 目前正在进行的临床试验为BCG不响应NMIBC患者提供了有希望的结果.
- 像Oportuzumab Monatox这样的新药正在接受调查.
结论:
- 对于BCG不响应的NMIBC,需要有效的膀节约选择.
- 当前和新兴疗法为改善患者的治疗结果提供了希望.
- 在临床试验中招募患者对于推进治疗至关重要.
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