非类固醇抗炎药对术后妄想的作用:一个元分析
Su Yeon Kim1, Hyo-Seok Na1,2, Jung-Hee Ryu1,2
1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Korean journal of anesthesiology
|August 6, 2024
概括
在对八项研究的元分析中,非类固醇抗炎药物 (NSAID) 显著降低了术后狂妄症,疼痛和阿片类药物使用的发生率. 这表明NSAID可能是管理术后康复的宝贵工具.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 神经炎症是术后妄想的一个被提议因素.
- 研究非类固醇抗炎药物 (NSAIDs) 在缓解这种疾病中的作用至关重要.
研究的目的:
- 评估NSAID使用对手术后狂妄症发生率的影响.
- 评估NSAID对术后疼痛和阿片类药物消费的影响.
主要方法:
- 在主要的电子数据库中进行了系统的文献搜索.
- 包括随机对照试验,评估NSAID使用与安慰剂或没有治疗.
- 主要结局:术后妄想发病率;次要结局:疼痛评分和阿片类药物消费.
主要成果:
- 对8项研究 (1238名参与者) 的分析显示,NSAID使用显著降低了狂妄发作 (OR:0.54,95% CI [0.38,0.7]).
- 无 NSAID 药物也显著降低了术后疼痛 (MD: -0.75,95% CI [-1.37, -0.13]) 和阿片类药物消费 (MD: -2.88,95% CI [-3.54, -2.22]).
结论:
- 服用NSAID有效降低了手术后痴呆症的发生率.
- 无抗炎药物有助于减少术后疼痛和减少阿片类药物需求.
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