口腔恶性潜在疾病:需要改变,为研究,政策和实践提供信息
Antonio Celentano1, Nicola Cirillo1
1Melbourne Dental School, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
概括
目前的口腔潜在恶性疾病分类是不切实际的. 建议修订系统,根据实际口腔癌风险对疾病进行分类,从癌前到全身疾病,以改善诊断和患者护理.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 目前口腔潜在恶性疾病 (OPMDs) 的分类将许多疾病标记为癌前.
- 许多OPMD的实际恶性转变率很低,导致潜在的过度诊断和患者负担.
- 现有的分类没有充分区分口腔癌发展的不同风险.
研究的目的:
- 批判性地检查OPMDs的当前分类.
- 提出一个修订后的分类系统,反映出不同的口腔癌风险.
- 引导OPMDs的研究,政策和临床管理.
主要方法:
- 对现有的OPMD分类进行批判性审查.
- 基于恶性瘤风险的新分层分类系统的开发.
- 口腔病变和疾病的分类:口腔癌前疾病,口腔潜在的前恶性疾病和口腔恶性潜在的系统性疾病.
主要成果:
- 拟议的分类包括三个层次:口腔癌前疾病 (高风险),口腔潜在的前恶性疾病 (有限/未定义的风险) 和口腔恶性潜在的系统性疾病 (没有前体病变的风险增加).
- 具体的例子为每个类别提供,包括红细胞,白血,口腔下纤维化和遗传/系统性疾病.
- 该框架旨在比目前的系统更准确地区分风险水平.
结论:
- 需要对OPMD进行修订分类,以反映不同的恶性瘤风险.
- 拟议的分层系统为临床实践,研究和政策提供了实际指导.
- 这种方法可以帮助减轻过度诊断,并减少与OPMD标签相关的患者焦虑.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
06:11Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
9.8K
相关概念视频
01:15Teeth
366
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
366
01:03Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:21Tooth Anatomy
403
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
403
01:11Oral Cavity
548
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
548
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K