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Updated: Apr 13, 2026

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在由NeuroD1/Ascl1/Dlx2诱导的天体细胞转化为神经元过程中,天体细胞属性的特征性变化

Qing He1, Zhen Wang, Yuchen Wang

  • 1GHM Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.

Neural regeneration research
|August 6, 2024
PubMed
概括

神经转录因子如NeuroD1,Ascl1和Dlx2直接将反应性天体细胞转化为成年大脑中的新神经元. 这一发现为神经损伤和神经疾病提供了一个有希望的治疗途径.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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