5和10毫克登佩西尔在改善痴呆患者认知功能的有效性:系统性审查和元分析
Mehak Sheikh1, Mohammad Ammar2
1Faculty of Pharmaceutical Sciences (FOP), University of Central Punjab, Lahore, Pakistan.
Frontiers in neuroscience
|August 6, 2024
概括
每天服用5毫克和10毫克的多尼佩齐尔可以改善痴呆症患者的认知功能. 与安慰剂相比,10mg剂量在提高认知得分,特别是MMSE方面显示出更大的有效性.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 痴呆症显著影响认知功能.
- 多尼佩西尔是一种常用于痴呆症的药物.
- 关于最佳剂量用于认知改善的证据需要系统评估.
研究的目的:
- 与安慰剂相比,系统地评估每日5mg和10mg剂量的多内佩西尔的有效性.
- 评估donepezil对任何阶段痴呆症患者认知功能的影响.
主要方法:
- 在过去20年内发表的18项随机对照试验 (RCT) 的系统综述和元分析.
- 搜索了多个数据库,包括Medline,Scopus,Embase,科学网和科克兰图书馆.
- 使用ADAS-cog和MMSE尺度来测量结果,并使用IBM SPSS分析数据.
主要成果:
- 分析包括1,556名接受5毫克多内佩西尔治疗的患者,2,050名接受10毫克多内佩西尔治疗的患者和2,342名接受安慰剂治疗的患者.
- 多内佩齐尔10毫克/天显著改善了迷你精神状态检查 (MMSE) 的得分.
- 多尼西尔5毫克/天在MMSE得分上略有改善,但这两种剂量都没有显著降低阿尔茨海默病评估尺度-认知 (ADAS-cog).
结论:
- 每日服用5mg和10mg的多内佩齐尔对痴呆症患者的认知功能有好处.
- 与5mg剂量相比,每日10mg的多内佩西尔剂量在改善认知功能方面似乎更有效.
- 可能需要进一步的研究来探索对ADAS-cog分数的影响.
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