艾滋病毒流行地区的心血管血栓性中风:诊断不足和严重
Eitzaz Sadiq1, Angela Woodiwiss2, Gavin Norton2
1Division of Neurology, Department of Neurosciences, University of the Witwatersrand Johannesburg Faculty of Health Sciences, Johannesburg, South Africa.
BMJ neurology open
|August 6, 2024
概括
心血管栓塞性中风 (CES) 在撒哈拉以南非洲艾滋病毒感染者 (PLWH) 中比以前认为的更常见和更严重. 心肌病是主要的心脏病原因,这表明需要有针对性的诊断方法.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 心血管栓塞性中风 (CES) 是撒哈拉以南非洲 (SSA) 艾滋病毒感染者中风的罕见原因,但由于诊断限制,这可能是低估的.
- 导致SSA中PLWH中CES的特定心脏病理尚不清楚.
研究的目的:
- 确定SSA中的PLWH中CES的流行率和病因.
- 将PLWH中的CES与HIV阴性中风患者进行比较.
主要方法:
- 一项横截面研究,将85名新发性中风的PLWH与109名年龄和性别匹配的HIV阴性中风患者进行比较.
- 进行了全面的中风病因调查,包括心电图,心声学,CT血管学和CSF检查.
主要成果:
- 在20.0%的PLWH中发现了CES,比之前报告的更高的患病率.
- 与没有CES的PLWH相比,中风更严重 (NIHSS 14.9 vs 11.7).
- 心肌病是PLWH中占主导地位的心脏病理 (76.4%),而肺病在HIV阴性患者中更为常见 (42.4%).
结论:
- 在SSA中,CES可能被诊断不足,在PLWH中更严重.
- 心肌病是这一群体中CES的主要心脏病因,表明需要可访问的诊断生物标志物.
更多相关视频
相关概念视频
Sexually Transmitted Infections
292
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
292
Ischemic Heart Disease: Overview
1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
Immunodeficiency Diseases
928
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
928
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Disorders of Hemostasis
768
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
768


