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在结直肠癌进展中Tregs和ICOS诱导的M2巨细胞两极化之间的相关性

Jiaxin Xu1, Yu Gao2, Yuting Ding3

  • 1The Second Ward of Colorectal Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.

Frontiers in oncology
|August 6, 2024
PubMed
概括

调节性T细胞 (Tregs) 通过通过ICOS诱导M2巨细胞促进结直肠癌 (CRC) 的进展. 较高的ICOS水平与CRC患者的更好的生存率相关.

关键词:
这就是ICOS ICOS.M2 大细胞这是Tregs.结肠直肠癌是什么意思

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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