中国草药对男性因子不孕症的影响:随机对照试验的研究方案
Qidan Wen1, Huanying Xu1,2, Haoxi Zou1
1Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.
Frontiers in endocrinology
|August 6, 2024
概括
这项研究调查了中国草药 (CHM) 治疗男性因子不孕症,这是全球不孕症的常见原因. 该试验旨在确定CHM是否改善活产率,提供一种潜在的新治疗选择.
科学领域:
- 生殖医学 生殖医学
- 传统中国医药 传统中国医药
- 临床试验 临床试验
背景情况:
- 男性因子不孕症影响全球40-60%的不孕症病例.
- 对于男性不孕症的传统治疗有局限性,包括成本,侵入性和不良影响.
- 中国草药 (CHM) 显示出改善精子质量和减少氧化应激的潜力,但缺乏关于活产率的强有力的证据.
研究的目的:
- 评估中国草药 (CHM) 在改善男性因子不孕症活产率方面的疗效和安全性.
- 为CHM作为治疗男性不孕症提供基于证据的支持.
- 探索CHM对精液参数和怀孕结果的影响.
主要方法:
- 一个单中心,随机,等候名单受控试验,涉及250对男性因子不孕症夫妇.
- 参与者按1:1随机分配,每天接受3个月的CHM或3个月的等候名单期.
- 主要结果是活产率,次要结果包括精液质量,DNA碎片化指数 (DFI) 和怀孕结果,经过12个月的跟踪.
主要成果:
- 该部分是在研究完成后填写的.
结论:
- 这项试验将确定CHM是否是男性因子不孕症的有效和安全治疗方法.
- 结果可能为因男性因素而导致不孕症的夫妇提供一种新的治疗策略.
- 这项研究旨在解决目前关于CHM对男性不孕症活产率影响的证据缺口.
相关概念视频
Infertility in Males
256
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
256
Spermatogenesis
102.3K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.3K
Disorders of the Male Reproductive System
370
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
370
Infertility in Females
288
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
288


