在Sjogren病中角膜上皮厚度:试点研究
Brian J Nguyen1, Angela S Gupta1, Jocelyn He1,2
1Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Clinical ophthalmology (Auckland, N.Z.)
|August 6, 2024
概括
斯乔格伦病患者表现出较薄的上角膜上皮质和与减少眼产生的变异性增加. 需要进一步的研究,以探索角膜上皮厚度 (CET) 在眼表面疾病.
科学领域:
- 眼科医生 眼科 眼科
- 角质科学 角质科学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 斯约格伦病 (SjD) 是一种自身免疫性疾病,会影响外分泌腺,经常导致眼睛表面的并发症.
- 角膜上皮厚度 (CET) 的变化可能作为SjD患者眼球表面健康的指标.
研究的目的:
- 在被诊断患有Sjogren病 (SjD) 的患者中评估角膜上皮厚度 (CET).
- 调查CET与临床特征和SjD症状之间的关联.
主要方法:
- 对SjD患者的回顾性图表审查 (2021年9月 - 2022年1月).
- 用前段OCT在中心和同心区域测量角膜上皮厚度.
- 分析患者的人口统计数据,希尔默测试,血清学标记和眼睛表面疾病指数 (OSDI) 评分.
主要成果:
- 分析了15名SjD患者 (100%为女性,平均年龄为58.4岁).
- 与下层表皮相比,上角膜表皮显著较薄 (p=0.001).
- 表皮厚度的变化与未麻醉的希尔默测试结果相反相关 (r=-0.39,p=0.005).
结论:
- SjD患者表现出明显的上方与下方角膜上皮质稀薄.
- 角膜上皮质厚度的变化与SjD中眼产生的减少有关.
- 需要进行更大规模的研究,以将CET与对眼表面疾病的客观和主观测量相关联.
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