咳在两代人的遗传性:RHINESSA研究
Össur Ingi Emilsson1,2, Henrik Johansson3, Ane Johannessen4
1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
ERJ open research
|August 6, 2024
概括
父母慢性咳增加后代患咳的可能性,这表明一种遗传特征. 具体的咳类型,无论是生产性还是非生产性,都会被后代遗传.
科学领域:
- 遗传学 是一个遗传学.
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- 慢性咳的遗传性仍然没有得到充分的研究.
- 了解咳的家族聚合对于公共卫生至关重要.
- 以前的研究没有根据咳类型区分遗传性.
研究的目的:
- 为了研究慢性咳的遗传性.
- 为了确定父母咳是否预测后代咳.
- 检查咳的遗传性是否在生产性咳和非生产性咳之间有所不同.
主要方法:
- 使用RHINESSA世代研究队列 (7155名父母,8176名后代).
- 使用详细问卷来评估父母和后代的慢性咳 (生产性/非生产性).
- 应用混合效应逻辑回归,调整多个共变量.
主要成果:
- 父母患有非生产性咳的后代患有非生产性咳的几率增加了1.59倍 (aOR为1.59).
- 父母患有生产性咳的后代患有生产性咳的几率增加了1.34倍 (aOR1.34).
- 在父母和后代咳之间没有观察到交叉类型的关联.
结论:
- 慢性咳似乎是一种遗传性特征,独立于父母的喘.
- 特定类型的慢性咳 (生产性或非生产性) 是遗传性的.
- 家庭咳模式表明生产性和非生产性咳的遗传影响是不同的.
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