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Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
在非ST升高心肌梗塞后的八十岁人群中心肌损伤和临床结果
Toni Pätz1, Thomas Stiermaier1, Moritz Meusel1
1Department of Cardiology, Angiology and Intensive Care Medicine, German Center for Cardiovascular Research (DZHK), University Heart Center Lübeck, Medical Clinic II, University of Lübeck, Lübeck, Germany.
患有非ST升高心肌梗塞 (NSTEMI) 的老年患者 (≥80岁) 在一年内经历了更多重大心脏不良事件 (MACE). 然而,心脏磁共振 (CMR) 显示了类似的心肌损伤,年龄不是结果的独立预测因素.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 老年医学 老年医学
背景情况:
- 非ST升高心肌梗塞 (NSTEMI) 是一种常见的心脏紧急情况.
- 评估心肌损伤和临床结果的年龄相关差异对于有效的患者管理至关重要.
研究的目的:
- 调查心肌损伤的年龄相关差异和NSTEMI后的一年临床结果.
- 为了确定NSTEMI患者中主要不良心脏事件 (MACE) 的预测因素.
主要方法:
- 在440名NSTEMI患者的前性多中心研究中.
- 心脏磁共振 (CMR) 影像检查,在输入后1-10天.
- 小组的比较:<80岁与≥80岁.
- 对MACE (死亡,复发性心脏病发作,充血性心力衰竭) 的1年随访.
主要成果:
- 高龄患者 (≥80岁) 占该队列的13.9%.
- 在心脏病发作大小,微血管阻塞或通过CMR的喷射分数方面没有显著差异.
- 在≥80岁 (19.7%) 和<80岁 (9.6%) (p=0.019) 的患者中,MACE的发生率显著更高.
- MACE的独立预测因素:患病血管数量,阿尔多激素对抗剂的使用,以及左心室全球纵向菌株.
结论:
- 心肌损伤在年轻和老年NSTEMI患者之间是可比的.
- 尽管老年人患病率较高,但年龄并不是1年临床结果的独立预测因素.
- 临床管理应考虑NSTEMI患者的年龄以外的因素.
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