白天小睡,发生的心房动和痴呆症的动态转变
Chenglong Li1,2, Daijun He3,4,5,6,7, Chao Yang3,4,5,6,7,8
1National Institute of Health Data Science at Peking University, Beijing, China.
JACC. Advances
|August 6, 2024
概括
频繁的白天小睡会增加心房动 (AF) 的风险,并导致痴呆症转变为AF. 左心室喷射分数调解了这一关联,这表明小睡是潜在的查指标.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 午睡和发生性心房动 (AF) 之间的关联是未知的.
- 很少有研究探讨了AF和痴呆症之间的动态过渡.
- 睡眠行为对心血管和神经健康的作用需要进一步调查.
研究的目的:
- 为了评估午睡和事件AF之间的关联.
- 为了检查AF和痴呆症之间的动态过渡.
- 为了研究左心室 (LV) 大小和功能的调解途径.
主要方法:
- 利用了来自476,588名参与者的英国生物库数据.
- 评估小睡频率和其他睡眠行为.
- 采用多状态生存分析和心血管磁共振成像用于LV功能.
主要成果:
- 经常小睡与AF风险增加1.17倍相关,独立于其他睡眠行为.
- 在午睡和AF之间的关联中,LV喷射分数介导了26.2%.
- 经常小睡也增加了从AF过渡到AF的风险,与痴呆症并发症.
结论:
- 查小睡可能是重要的,因为它与发生的AF和痴呆症有关.
- 常规的LV喷射分数评估可以帮助识别习惯性午睡者中的AF发作.
- 午睡行为在心血管和痴呆症风险评估中需要考虑.
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