试剂注射的有效性和安全性作为一种干预性玻璃眼治疗方法,用于不受控制的开角玻璃眼
Gabriele Vizzari1, Piero Ceruti1
1Department of Ophthalmology, Hospital Mater Salutis Legnago, Legnago, Verona, Italy.
European journal of ophthalmology
|August 6, 2024
概括
该iStent注射有效降低眼内压力,并减少早期绿眼病患者的药物需求. 这种独立的手术显示出高达24个月的显著IOP控制,改善了患者的生活质量.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 最少侵入性玻璃眼外科手术
背景情况:
- 青光眼的管理往往需要终身药物治疗,并且可以在治疗中取得进展.
- 早期的开角青光眼 (OAG) 对持续的眼内压力 (IOP) 控制构成重大挑战.
- 该iStent注射提供了一个潜在的最少入侵的选择独立治疗.
研究的目的:
- 评估iStent注射作为早期不受控制的OAG患者的独立程序的疗效和安全性.
- 为了评估24个月的随访期间内脉压降低和药物需求的变化.
- 为了确定这种微创性玻璃眼手术的长期结果.
主要方法:
- 一个回顾性,单中心病例系列包括88只眼睛的OAG患者和不受控制的IOP在1-4种药物上.
- 患者接受了iStent注射植入作为一个独立的程序.
- 主要结局包括基线IOP和药物计数,以及植入后6,12,18和24个月.
主要成果:
- 平均IOP从基线时的20.54 mmHg下降到24个月后的16.15 mmHg (p < 0.001).
- 在24个月内,绿眼瘤药物的平均数量从2.35下降到1.31 (p < 0.001).
- 在24个月后,91%的眼睛内血压≤18mmHg,14.1%的眼睛没有药物治疗,没有严重的不良事件.
结论:
- 独立的iStent注射植入是有效的控制IOP在早期阶段OAG.
- 该程序显著减少了对青光眼药物的需求,提高了患者的生活质量.
- iStent 注射在长期治疗青光眼中表现出有利的安全性.
相关概念视频
01:27Open Angle Glaucoma: Treatment
413
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
413
01:28Angle Closure Glaucoma: Treatment
459
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
459
01:25Glaucoma: Overview
530
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
530
01:22Drug Delivery: Miscellaneous Routes
330
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
330