囊性纤维化中的前肠
Christopher Vélez1, Isabel Neuringer2, Sarah Jane Schwarzenberg3
1Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pediatric pulmonology
|August 6, 2024
概括
囊性纤维化 (CF) 肺部疾病由与肠道相关的吸收 (GRASP) 恶化,这是一种涉及GERD和胃的疾病. 有效的GRASP管理,解决这两种情况,对于改善CF患者的肺功能至关重要.
科学领域:
- 空气消化道胚胎学和生理学
- 囊性纤维化 (CF) 病理生理学
- 胃肠道 (GI) 和呼吸系统的相互作用
背景情况:
- 空气消化器官具有共同的胚胎起源,在患有囊性纤维化 (pwCF) 的人群中影响其功能.
- 消化道和呼吸系统的相互联系对于理解CF进展至关重要.
- 像GER和GERD这样的现有术语不足以描述pwCF中的复杂病理.
研究的目的:
- 引入和定义一个新的术语,肠道相关吸入 (GRASP),用于在pwCF中将前肠内容物吸入呼吸道.
- 解释包括GERD和胃衰竭在内的GRASP如何导致pwCF肺部疾病恶化.
- 突出了对CF中GRASP标准化临床管理算法的需要.
主要方法:
- 航空消化道胚胎学和神经解剖学对照的审查.
- 在pwCF中,分析病理生理学,将前肠功能障碍与肺损伤联系起来.
- 讨论构成GRASP的双重疾病过程 (GERD和胃衰竭).
主要成果:
- GRASP是GERD和胃衰竭的组合,被认为是pwCF.正常状态的重要障碍.
- 从十二指肠到呼吸道树的前肠内容的吸入有助于肺损伤.
- 目前针对CF的胃肠道症状的管理策略不足,缺乏呼吸系统方面的考虑.
结论:
- 通过解决GERD和胃衰竭,有效地管理GRASP对于改善 pwCF 肺部健康至关重要.
- 对GRASP的标准化临床管理算法是一个关键的研究缺口.
- 未来的研究应该专注于减少GRASP的影响,以改善pwCF的结果,特别是肺移植后的结果.
相关概念视频
01:23Cystic Fibrosis: Pathogenesis
201
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
201
01:24Cystic Fibrosis: Management
150
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
150
01:27Histology of the Small Intestine
617
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
617
01:50What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
01:26Physiology of the Gastrointestinal System III: Elimination
231
The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
231
01:16Gross Anatomy of the Stomach
635
The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
635