关于囊性纤维化结肠直肠癌风险和当前查建议的不断变化的数据:移植前和移植后:
Zain Raza1, Bianca N Islam2,3, Christine Y Hachem1
1Department of Internal Medicine, Division of Gastroenterology & Hepatology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Pediatric pulmonology
|August 6, 2024
概括
囊性纤维化 (CF) 患者的预期寿命延长需要关注与衰老相关的疾病,如早期发病的结直肠癌 (CRC). 目前的指导方针建议CF患者进行结肠镜检查,未来的研究将探索非侵入性查和CFTR调节器对CRC风险的影响.
科学领域:
- 医学 医学 医学 医学 医学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 囊性纤维化 (CF) 治疗的进步,包括CFTR调节器,显著增加了患者的预期寿命.
- 这种人口变化需要更多地关注CF人口中与年龄相关的疾病.
- 早期结直肠癌 (CRC) 是CF的一个显著并发症,特别是在严重的突变和移植后.
研究的目的:
- 为了突出结肠直肠癌 (CRC) 在衰老的囊性纤维化 (CF) 患者的风险增加.
- 讨论囊性纤维化转膜导体调节器 (CFTR) 在结直肠癌发生中的作用.
- 概述目前的查建议和CF中CRC的未来研究方向.
主要方法:
- 关于CF,衰老和结直肠癌的当前文献的综述.
- 分析CFTR作为瘤抑制剂的作用.
- 审查现有的囊性纤维化基金会查指南.
主要成果:
- 缺乏CFTR表达与致癌过程有关,包括肠道炎症和微生物组变化.
- 肌痛性瘤患者被认为是CRC的高风险患者,因此需要专门的查方案.
- 目前的建议包括从40岁 (没有移植) 或30岁 (移植后) 开始的结肠镜查,随着监测间隔的变化.
结论:
- 增加CF患者的寿命需要主动管理与年龄相关的并发症,如CRC.
- CFTR功能障碍有助于CRC的发展,支持CF患者被归类为高风险患者.
- 需要对非侵入性CRC查工具和CFTR调节器对CRC风险的影响进行进一步的研究.
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