尼日利亚人的多种药物和生活质量,主要是开角玻璃眼
Chinasa Anderline Nnubia1, Sebastian Ndulue Ntuko Nwosu1,2, Nonso Ejikeme Okpala1,2
1Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria.
European journal of ophthalmology
|August 6, 2024
概括
在尼日利亚,青光眼药物的数量并没有显著影响患者的生活质量. 虽然副作用随着更多的药物增加而增加,但整体生活质量仍然独立于治疗复杂性.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 主要开角青光眼 (POAG) 是全球不可逆转失明的主要原因.
- POAG的医疗管理通常涉及多种药物来控制眼内压力.
- 多药对患者报告结果 (如生活质量) 的影响需要进一步研究.
研究的目的:
- 评估多发性玻璃眼药物对初级开角玻璃眼 (POAG) 患者的生活质量 (QoL) 的影响.
- 在尼日利亚接受医疗治疗的POAG患者中调查药物数量与QOL之间的关系.
主要方法:
- 招募了171名接受药物治疗的成人POAG患者的系统样本.
- 收集的数据包括社会人口统计数据,药物细节和不良影响.
- 使用国家眼科研究所视觉功能问卷-25 (NEI-VFQ-25) 测量生活质量.
主要成果:
- 63.7%的患者使用多种药物,副作用比例增加.
- 随着药物数量的增加,平均QOL得分下降 (单疗法:89.3,双疗法:80.2,≥三疗法:78.9).
- 双变量分析显示了显著的关联 (P<0.01),但多重回归显示,在调整混因子后,药物数量对QoL没有独立的影响 (p=0.881).
结论:
- 在这个尼日利亚队列中,青光眼药物的数量不是生活质量的独立预测指标.
- 在这项研究中,视力敏度和青光眼的严重程度也没有独立地与QoL相关.
- 这些发现表明,除了药物计数之外的因素影响POAG患者的QoL.
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