在肝硬化和没有肝硬化患者中,胃肠道出血的比较
Sara Margret Daðadóttir1, Arnar Bragi Ingason2, Johann Pall Hreinsson3
1Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Scandinavian journal of gastroenterology
|August 6, 2024
概括
肝硬化患者的胃肠道出血 (GIB) 通常是由静脉或引起的,与非肝硬化患者不同. 虽然GIB死亡率相似,但肝硬化患者的整体死亡率更高.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 上部胃肠道出血 (GIB) 在肝硬化患者中得到了充分记录.
- 然而,专注于该人群中较低GIB的研究是有限的.
- 这项研究旨在阐明GIB在肝硬化和没有肝硬化患者中的特征.
研究的目的:
- 为了比较患有肝硬化和没有肝硬化的患者GIB的临床特征,治疗方法和结果.
- 为了确定GIB在肝硬化患者和非肝硬化患者中的独特特征.
- 为了确定两组之间GIB原因和再出血率的差异.
主要方法:
- 一项回顾性研究包括从2010年到2021年因GIB住院的肝硬化患者.
- 一组非肝硬化患者的对照组以1:4的比例匹配.
- 包括标准是明显出血导致住院治疗.
主要成果:
- 在102名患有GIB的肝硬化患者中,有85%患有上部GIB,15%患有下部GIB.
- 肝硬化的常见原因包括急性水出血 (42%) 和 (40%),对照组分别为1%和6%.
- 胃和十二指肠在肝硬化患者中较少发生 (13%对31%和9%对29%).
- 肝硬化患者的复出血率更高 (14%对3%).
- 与GIB相关的死亡率较低 (1%与0.8%相比),但45天的整体死亡率在肝硬化患者中显著高 (10%与5%相比).
结论:
- 肝硬化患者的GIB经常与急性水出血和有关.
- 胃和十二指肠与非肝硬化患者相比,肝硬化患者的GIB原因较少.
- 尽管GIB特异性死亡率相似,但肝硬化患者的45天内总死亡率显著增加.
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