电治疗后预后因素和后动的发生率:系统性审查和元分析
Melissa Ertman, Emy S van der Valk Bouman1, Pascal R D Clephas2
1From the Departments of Neuroscience.
The journal of ECT
|August 6, 2024
概括
在电疗法 (ECT) 后发生的后脉动 (PIA) 影响了大约14%的患者. 虽然确定了许多因素,但在本系统性审查和元分析中,没有一个因素能够显著预测PIA发病率.
科学领域:
- 神经科学和精神病学 在
- 临床药理学 临床药理学
背景情况:
- 静脉后刺激 (PIA) 是电疗法 (ECT) 已知的不良影响之一.
- 现有的文献显示了PIA预后因素和发病率的不一致性.
- 了解PIA对于管理ECT副作用和患者安全至关重要.
研究的目的:
- 系统地审查和分析ECT后PIA的预后因素.
- 根据患者的人口统计和临床特征来确定PIA的发病率.
主要方法:
- 对追溯观察研究和RCT进行系统审查和元分析.
- 纳入标准:18岁以上的患者,客观的PIA发病率报告,以及预后因素的提取.
- 来自21篇文章的数据综合,涵盖66,047名患者.
主要成果:
- 确定了35个潜在的预后因素 (8个与麻醉相关,19个与患者相关,8个与ECT相关).
- 对7个因素的元分析显示,对PIA发病率没有显著影响.
- 平均PIA发病率为13.9% (患者级) 和12.4% (会话级);调整后的发病率更高.
结论:
- 尽管确定了许多因素,但在分析中,没有一个因素是统计学上显著的预测因素.
- 该研究强调,整体偏差风险中等至低,但结果测量风险高.
- 需要进一步进行高质量的研究,以澄清PIA的预测因素和因数据限制而导致的发病率.
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