Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

Search research articles

相关实验视频

Updated: Jun 17, 2025

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

Published on: June 6, 2025

在黑色素瘤中,GP100表达的强度是可变的.

Jacqueline E Mann¹, Nitzan Hasson¹, David G Su²

¹Division of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA.

Cancer immunology, immunotherapy : CII

|August 6, 2024

概括

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Diagnosis of granulomatous inflammation in thoracic small biopsies and fine needle aspiration specimens: a multi-institutional study.

Journal of the American Society of Cytopathology·2026

Same author

Development of [<sup>111</sup>In]In-CHX-A″-DTPA-αCD68 for ImmunoSPECT to Image Murine Macrophages.

Molecular pharmaceutics·2026

Same author

Immune checkpoint inhibitor therapy after tumor-infiltrating lymphocytes in unresectable melanoma.

Journal for immunotherapy of cancer·2026

Same author

Advances in Cancer Immunotherapy for Solid Tumors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Clinicopathologic characterization of renal tumors with Folliculin (FLCN) biallelic inactivation.

Virchows Archiv : an international journal of pathology·2026

Same author

Leading Consortiums from the Ground Up: Leveraging Trainee Collaboration to Create Consensus Guidelines.

Annals of surgical oncology·2026

转移性黑色素瘤中gp100表达率较高,但强度不同. 这一发现对于在皮肤黑色素瘤临床试验中选择患者接受Tebentafusp等gp100向疗法至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

由于其在黑色素细胞中的特异性,gp100是黑色素瘤治疗的目标.
针对gp100的双特异性抗体Tebentafusp在皮膜黑色素瘤中表现有前途,目前正在皮肤黑色素瘤中进行研究.
关于晚期皮肤黑色素瘤gp100表达水平的数据有限.

研究的目的:

为了研究gp100表达的程度和强度在一大群初级和转移性黑色素瘤.
评估gp100表达在不同黑色素瘤阶段的变异性.
为了告知患者选择gp100导向疗法.

主要方法:

免疫组织化学 (IHC) 用于评估原发性和转移性黑色素瘤样本中的gp100表达.
使用定量免疫光学来确认和量化gp100表达变异性.
对大量患者队列的分析提供了关于gp100表达模式的全面数据.

主要成果:

与初级相比,转移性黑色素瘤样本中的gp100表达在全球范围内更高.
在转移性黑色素瘤中,gp100表达几乎均呈阳性,但强度不同.
定量免疫光学证实了gp100表达水平的显著变化.

关键词:

葡萄糖蛋白100 葡萄糖蛋白100 是一种这就是ImmTAC的意义.黑色素瘤是一种黑色素瘤.有针对性的治疗.这是一个令人难以置信的标志.

更多相关视频

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

Experimental Metastasis Assay

Experimental Metastasis Assay

Published on: August 24, 2010

相关实验视频

Last Updated: Jun 17, 2025

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

Published on: June 6, 2025

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

Experimental Metastasis Assay

Experimental Metastasis Assay

Published on: August 24, 2010

结论:

gp100在转移性黑色素瘤中得到广泛表达,尽管表达强度有所不同.
了解gp100表达水平对于优化临床试验中的患者选择至关重要.
需要进一步研究药物活性与gp100表达水平的相关性,以提高治疗疗效.