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血质学参数和差差分化甲状腺癌和形性甲状腺癌的临床病理学特征的预测值

Dongmei Huang¹, Jinming Zhang¹, Xiangqian Zheng¹

¹Department of Thyroid and Neck Tumor, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.

Langenbeck's archives of surgery

|August 6, 2024

概括

血液学参数如D-二聚体,NLR和PLR,以及临床病理学特征,可以预测侵袭性甲状腺癌的预后,包括差分甲状腺癌 (PDTC) 和形甲状腺癌 (ATC). 这些因素为患者的治疗结果提供了宝贵的见解.

科学领域:

在瘤学瘤学.
血液学血液学血液学

背景情况:

差差分化的甲状腺癌 (PDTC) 和形甲状腺癌 (ATC) 是罕见的,具有有限研究和不良预后的侵袭性甲状腺癌.
识别预测标志物对于改善这些具有挑战性的恶性瘤患者的治疗结果至关重要.

研究的目的:

分析血液学参数和临床病理学特征的预测价值,以分析PDTC和ATC患者的预后.
确定与这些侵袭性甲状腺癌亚型的生存结果相关的因素.

主要方法:

在2007年至2019年期间,对67名被诊断为PDTC或ATC的患者进行了回顾性分析.
评估临床病理特征,血液学参数 (D-二分体,NLR,PLR) 和生存结果.

主要成果:

在死亡的患者中观察到较高的阳性D-二次体,高的中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR).
与PDTC (42.9%) 相比,无塑性甲状腺癌 (ATC) 的疾病相关死亡率 (93.8%) 显着更高.
平均整体存活期 (OS) 对于ATC (2.5个月) 比PDTC (56个月) 显著更短. 诊断时的年龄,NLR,PLR和D-二元与PDTC中的OS有关,而诊断时的年龄和手术与ATC中的OS有关.

结论:

血液学参数 (D-二聚体,NLR,PLR) 和临床病理特征,特别是诊断时的年龄,在PDTC和ATC的预后方面具有显著的预测价值.
这些发现可能有助于风险分层和个性化管理策略,为患有侵袭性甲状腺癌的患者.

关键词:

无塑性甲状腺癌是一种甲状腺癌.血液学参数血液学参数差差分化的甲状腺癌.预测预后预测预测生存结果的结果.

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