膜和ER在极地维度中的概括的神经动力学
Vora Hardagna Vatsal1, Brajesh Kumar Jha2, Tajinder Pal Singh1
1Department of Mathematics, School of Technology, Pandit Deendayal Energy University, Gandhinagar, Gujarat, India.
Cell biochemistry and biophysics
|August 6, 2024
概括
这项研究使用分数计算来模拟神经元动力学,揭示了像阿尔茨海默病一样的低缓冲水平如何提高并导致细胞死亡. 它还提出了缓冲策略,以保持最佳的神经元水平.
科学领域:
- 神经科学是一个神经科学.
- 生物物理学的生物物理.
- 计算生物学 计算生物学
背景情况:
- 离子作为关键的第二信使,调节细胞活动,精确的时空控制对神经可塑性和亡等大脑功能至关重要.
- 细胞内膜网膜 (ER) 和STIM-Orai通道显著影响细胞质动态,这可能表现出异常行为.
研究的目的:
- 开发一个数学模型模拟神经元离子动态使用分数计算.
- 研究不同缓冲水平对神经元健康的影响,特别是在神经系统疾病的背景下.
- 提出基于缓冲的干预措施,以维持最佳的细胞内度.
主要方法:
- 在极坐标中使用卡普托分数微分演算子来建模离子相互作用.
- 在分析解决方案中使用混合积分转换方法.
- 使用格林函数推导出一个封闭形式的溶液,从而产生米塔格-莱弗勒类型的函数.
主要成果:
- 模拟表明,度下降的结果来自时间和空间的差异过渡.
- 异常低的缓冲水平与阿尔茨海默病的特征度升高有关,导致神经元死亡.
- 这项研究确定了S100B,BAPTA和calmodulin作为维持神经元平衡的关键缓冲剂.
结论:
- 分数计算为模拟神经元中复杂的动态提供了一个强大的框架.
- 改变缓冲显著影响神经元功能和生存,对神经退行性疾病有影响.
- 拟议的缓冲策略为通过失调的特征的神经疾病提供了潜在的治疗途径.
相关概念视频
Feedback Regulation of Calcium Concentration
3.4K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.4K
Resting Membrane Potential
18.4K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
18.4K
The Resting Membrane Potential
131.6K
Overview
131.6K
Calmodulin-dependent Signaling
5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.1K
Assembly of the Lipid Bilayer in the ER
3.1K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
3.1K
The Endoplasmic Reticulum
12.7K
The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
12.7K


