在早期发生的精神分裂症中,甲状腺皮质回路的功能障碍
Jia Cai1, Min Xie1, Sugai Liang2
1Mental Health Center, West China Hospital of Sichuan University, No. 28th Dianxin Nan Str. Chengdu, Sichuan, 610041, China.
Cerebral cortex (New York, N.Y. : 1991)
|August 6, 2024
概括
这项研究揭示了早期精神分裂症中明显的thalamocortical电路差异,识别了关键大脑网络中的改变连接. 这些发现突出了皮层脱节作为这种情况的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 丘陵体在功能性脑电路中起着至关重要的作用.
- 在精神分裂症中,thalamocortical电路的改变与精神分裂症有关.
- 了解早期精神分裂症中的这些电路是有限的.
研究的目的:
- 为了研究早期精神分裂症的thalamocortical电路连接.
- 为了确定受 thalamocortical disconnections 影响的特定大脑网络.
- 探索早期精神分裂症的潜在生物标志物.
主要方法:
- 招募了110名患有早期精神分裂症的参与者和70名健康对照.
- 使用静止状态功能和扩散权重磁共振成像.
- 采用数据驱动的分 parcellation 方法来对 thalamus 进行细分.
主要成果:
- 早期发病的精神分裂症显示了thalamic分区和前面对面,视觉,腹部注意力和体运动网络以及小脑之间的低连接性.
- 在thalamic分区和边缘网络区域 (近海马和回) 之间观察到超连接性.
- 右后侧带带皮层连接与thalamic分区与一般精神病理学分数相关.
结论:
- 涉及前额叶,听觉,视觉皮层和小脑的特定thalamocortical失联的特征是早期发病的精神分裂症.
- 塔拉皮质连接性改变可能成为早期精神分裂症的潜在生物标志物.
- 准thalamocortical电路可能为早期精神分裂症提供新的治疗途径.
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