肠道微生物组成在肉症中发生变化:临床研究的系统审查和元分析
Xiaohong Mai1, Shuyi Yang2, Qifeng Chen3
1Department of Geriatric Psychiatry, Shaoxing Seventh People's Hospital, Shaoxing, China.
PloS one
|August 6, 2024
概括
萨科佩尼亚与肠道微生物群丰富度的减少有关. 像Prevotellaceae这样的特定细菌可能有助于预防和治疗这种消耗肌肉的疾病.
科学领域:
- 微生物组研究的研究.
- 老年学是一门学科.
- 肌肉骨健康 肌肉骨健康
背景情况:
- 肠道微生物群 (GM) 通过新陈代谢和免疫力影响肌肉骨疾病.
- 一种肌肉消耗性疾病 - - 萨尔科佩尼亚,可能与肠道功能失调有关.
- 了解转基因的作用对于预防和治疗肉症至关重要.
研究的目的:
- 系统地审查和分析关于肠道微生物群多样性的人类研究.
- 为了识别特定的肠道细菌,可以作为sarcopenia的生物标志物.
- 探索肠道微生物群组成和萨科佩尼亚病理生理学的关系.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统搜索,截至2024年2月16日.
- 纳入了19项研究,包括65,65名参与者,分析了在肉症中的肠道微生物群.
- 使用乔安娜·布里格斯研究所的标准评估研究质量和GRADE的证据确定性.
主要成果:
- 与对照组相比,sarcopenia患者的微生物丰富度显著降低 (Chao1,观察到的物种,ACE指数).
- 大多数研究和参与者都观察到肠道微生物群组成 (β-多样性) 的显著差异.
- 在患有肉症的人群中,注意到了Prevotellaceae,Prevotella和Megamonas的丧失.
结论:
- 萨科佩尼亚与肠道微生物群丰富度降低和组成变化有关.
- 恢复特定的肠道细菌 (Prevotellaceae,Prevotella,Megamonas) 可能有助于预防和治疗肉症.
- 对肠道微生物群调节的进一步研究可能为肉类症提供新的治疗策略.
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