埃托米达作为Colosoma macropomum中的麻醉剂:行为和电生理学数据相互补充,作为评估麻醉剂安全性的工具
Thaysa de Sousa Reis1, Daniella Bastos de Araújo1, Clarissa Araújo da Paz1
1Laboratory of Pharmacology and Toxicology of Natural Products, Biological Science Institute, Federal University of Pará, Belém, PA, Brazil.
PloS one
|August 6, 2024
概括
埃托米达有效地麻醉了tambaqui鱼,较低的剂量 (2-3 mg/L) 确保了快速恢复. 较高度减缓恢复,影响水产养殖过程中的鱼类福利.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 鱼类麻醉 鱼类麻醉
- 动物福利 动物福利
背景情况:
- 麻醉剂对于最大限度地减少养殖和装饰鱼的压力至关重要.
- 了解麻醉效应对于鱼类福利和管理至关重要.
研究的目的:
- 为了研究etomidate在tambaqui中的行为,心电图和通风效应.
- 为了确定安全有效的etomidate度用于tambaqui麻醉.
主要方法:
- 年轻的tambaqui (n=99) 被暴露在以 2-4 mg/L 的度的埃托米达浴中.
- 在诱导和恢复期间分析了行为反应,心电图和手术动作.
主要成果:
- 在较高的埃托米达度下,麻醉诱导速度更快,但恢复时间较长.
- 埃托米达导致心率 (高达69.19%) 和呼吸率 (高达40.70%) 的剂量依赖性降低.
- 在康复期间,心肺呼吸系统参数恢复正常,没有观察到兴奋性.
结论:
- 埃托米达在短期的tambaqui麻醉中是安全的,剂量为2-3毫克/升.
- 较高的埃托米达剂量导致麻醉可逆性减缓和显著的心肺呼吸系统抑郁.
- 最佳的埃托米达度对于水产养殖中安全的鱼类管理至关重要.
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