在动脉样硬化中的阿迪波涅丁和阿迪波涅丁受体
Ioanna Gianopoulos1, Christos S Mantzoros2,3, Stella S Daskalopoulou1,4
1Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec H4A 3J1, Canada.
阿迪波涅丁及其受体 (AdipoR1/R2) 调节巨细胞的两极分化,影响炎症并可能治疗动脉样硬化. 本综述探讨了它们在代谢健康和心血管保护中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 心血管生物学 心血管生物学
背景情况:
- 阿迪波涅丁是一种关键激素,它将脂肪组织与免疫和心血管系统联系起来.
- 在健康人群中,高水平的阿迪波内克可以改善胰岛素敏感性和脂肪酸氧化.
- 亚迪波涅丁通过调节巨细胞通过AdipoR1和AdipoR2.2的反应减轻动脉样硬化.
研究的目的:
- 审查阿迪波涅克丁及其受体对代谢和免疫反应的影响.
- 阐明阿迪波内克丁和阿迪波R1/R2在M1-M2巨细胞两极化中的作用.
- 讨论它们作为动脉样硬化炎症治疗点的潜力.
主要方法:
- 文献综述侧重于巨细胞中的皮菌素信号传递.
- 对调查M1-M2巨分化研究的研究分析.
- 检查阿迪波内克在动脉保护中的作用.
主要成果:
- 亚迪波涅的信号影响着巨细胞的两极分化,使其进入一种类似M2的抗炎状态.
- 阿迪波R1和阿迪波R2在调解这些影响方面有着不同的,细微的作用.
- 阿迪波涅克丁通路在减轻动脉样硬性斑块炎症方面表现有前途.
结论:
- 和它的受体是巨细胞表型和功能的关键调节者.
- 向阿迪波尼克丁-阿迪波R通路为动脉样硬化提供了潜在的治疗策略.
- 需要进一步的研究才能充分利用它们的临床应用.
更多相关视频
06:56Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
Published on: July 21, 2023
07:36Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
相关概念视频
Adrenergic Receptors: ɑ Subtype
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Adrenergic Receptors (Adrenoceptors): Classification
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Receptor-mediated Endocytosis
Inflammation
