慢性疼痛与更新工作记忆特别相关:一项纵向双胞胎研究
Lydia Rader1,2, Tor D Wager3, Naomi P Friedman1,2
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States.
Pain
|August 6, 2024
概括
慢性疼痛与更差的执行功能有关,特别是更新工作记忆. 共同的遗传因素可能是这种联系的基础,这表明它在疼痛的发展中发挥了作用.
科学领域:
- 心理学 心理学 心理学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 更糟糕的执行功能 (EF) 与慢性疼痛有关,可能导致疼痛慢性化.
- 尚不清楚慢性疼痛是否涉及一般EF损伤或特定认知领域的缺陷.
- 在EF和慢性疼痛之间存在关联的遗传基础尚未得到研究.
研究的目的:
- 检查年轻成年人执行功能和慢性疼痛之间的表型和遗传关联.
- 确定特定认知领域的障碍,如更新工作记忆或改变心理设置,是否与慢性疼痛有独特的关联.
- 调查执行功能和慢性疼痛之间的共同遗传风险因素.
主要方法:
- 利用来自科罗拉多州纵向双胞胎研究的786名双胞胎的数据,评估23岁和28岁的执行功能.
- 定义了一个共同的EF因子,一个更新特定的因子和一个从执行职能任务中转移的特定因子.
- 稳定的EF变异 (年龄23-28岁) 和在平均年龄28岁时自我报告的慢性疼痛之间的估计表型和遗传相关性1.1.
主要成果:
- 现型分析显示慢性疼痛与更新特定EF因子 (r = -0.21,P = 0.008) 之间存在显著的负相关性.
- 在慢性疼痛和常见EF因子,转移特定因子或28岁独特的EF变异之间没有发现显著的表型相关性.
- 一个双胞胎模型表明慢性疼痛和更新特异性EF因子 (rA = -0.46,P = 0.005) 之间存在显著的共同遗传风险,但没有共同的环境风险.
结论:
- 更新工作记忆显示出与年轻成年人的慢性疼痛有显著的表型和遗传关系.
- 更新工作记忆的能力受损可能在慢性疼痛的发展中起到机械作用.
- 这些发现强调了认知因素的重要性,特别是工作记忆更新,以了解慢性疼痛.
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