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Updated: Jun 3, 2026

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
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用对称和不对称的同质甘氨酸编制66-IgG库及其功能评估

Shino Manabe1,2, Shogo Iwamoto3, Satoru Nagatoishi4,5

  • 1School of Pharmacy and Pharmaceutical Sciences and Institute of Medicinal Chemistry, Hoshi University, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

Journal of the American Chemical Society
|August 6, 2024
PubMed
概括

研究人员精确控制了抗体糖化,以调整IgG稳定性和效应器功能. 这种方法扩大了对同质甘氨酸及其对抗体性能的影响的研究.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...