在血栓塞栓性疾病中,Ficus benghalensis的治疗潜力
Anil Kumar Sahu1, Drishya Dinesh1, Vipin Kumar Verma1
1Cardiovascular Research Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Journal of Ayurveda and integrative medicine
|August 6, 2024
概括
(Ficus benghalensis L. (FB)) 具有显著的抗血栓性质,包括抗凝固和抗血小板作用. 这种传统的印度药用植物显示出开发新型,具有成本效益的血栓栓塞状况治疗方法的潜力.
科学领域:
- 植物医学 植物医学
- 药理学 药理学是指药理学的学科.
- 心血管研究研究心血管研究
背景情况:
- (Ficus benghalensis L. (FB)) 是一种植物,在传统印度医学中使用的历史悠久.
- 传统上,它用于治疗各种疾病,包括糖尿病,痢疾,白血病,小便,皮肤疾病,风湿症,炎症疾病和血液疾病.
- 本次审查重点关注FB的抗血栓性潜力.
研究的目的:
- 审查和强调Ficus benghalensis L.的抗血栓作用.
- 探索对这些影响负责的植物化学成分.
- 评估FB在开发用于血栓栓塞性疾病的新治疗策略方面的潜力.
主要方法:
- 在科学数据库中进行了全面的文献搜索:PubMed,谷歌学者,ScienceDirect和Scopus.
- 收集和分析了有关FB抗血栓性质和植物化学成分的数据.
- 审查了体外和体内研究的结果.
主要成果:
- 花 (Ficus benghalensis L.) 具有多种抗血栓性质,包括抗凝固剂,血小板抗聚合,抗动脉增生,低血压,低脂,抗炎和抗氧化作用.
- 这种植物含有丰富的植物化学物质,如类,黄类,类,类,类,类和类固醇,有助于其治疗作用.
- 来自各种研究的证据证实了这些成分在治疗血栓栓塞病的有效性.
结论:
- 花 (Ficus benghalensis L.) 显示出作为新型抗血栓剂的来源的巨大潜力.
- 它的植物化学特征支持其传统用途,并表明它在治疗心血管和血栓塞栓性疾病方面的作用.
- 进一步的研究可能会导致针对血栓栓塞性疾病的成本效益更高,更安全的药物开发.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
657
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
657
Clot Retraction and Fibrinolysis
5.1K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.1K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
502
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
502
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
Therapeutic Index
4.2K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
4.2K


