手,脚,口腔疾病流行病学变化 病因和促进因素
Nida Kalam1, Vinod Balasubramaniam1
1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
The American journal of tropical medicine and hygiene
|August 6, 2024
概括
手足口病 (HFMD) 是儿童的一种病毒感染. 最近引起肠道病毒的变化,如Coxsackievirus A6和A10,以及重组事件正在改变HFMD流行病学.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 手足口病 (HFMD) 是儿童常见的病毒性疾病,其特征是口腔和皮肤囊泡.
- 虽然通常是自我限制的,但严重的HFMD可能会导致严重的神经和呼吸道并发症.
- 肠道病毒,特别是肠道病毒A71 (EV-A71) 和Coxsackievirus A16,是主要的致病原体.
研究的目的:
- 为了研究HFMD病原体的不断变化的分子流行病学.
- 了解肠道病毒重组对HFMD疫情的影响.
- 为制定HFMD有效的预防和控制策略提供信息.
主要方法:
- 对导致HFMD的肠道病毒分子流行病学数据的分析.
- 在肠道病毒菌株之间识别和描述重组事件.
- 审查HFMD发病率,严重程度和死亡率的最近趋势.
主要成果:
- 流行HFMD病原体的显著转变,由coxsackievirus A6和coxsackievirus A10引起的感染增加.
- 有证据表明,肠道病毒菌株之间存在广泛的重组,这可能会影响血清型进化.
- 在幼儿和青少年中,与大脑干脑炎相关的死亡率增加.
结论:
- 了解HFMD病原体不断变化的流行病学和进化模式对于疾病控制至关重要.
- 新菌株和重组事件的出现需要持续的监测和研究.
- 目前的治疗选择有限,这凸显了预防策略和疫苗开发的重要性.
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