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Updated: Jun 17, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

孕产妇免疫激活及其对动物后代学习和记忆的多方面的影响:系统性审查

Saúl Sal-Sarria¹, Nélida M Conejo¹, Héctor González-Pardo¹

¹Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Oviedo, Spain; Institute of Neurosciences of the Principality of Asturias (INEUROPA), Oviedo, Spain; Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain.

Neuroscience and biobehavioral reviews

|August 6, 2024

概括

怀孕期间的母体免疫激活 (MIA) 会对后代的学习和记忆产生负面影响,男性通常更容易受到影响. 然而,一些研究表明增强认知,表明复杂的结果.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
免疫学免疫学免疫学

背景情况:

母亲免疫激活 (MIA) 越来越被认为是影响后代神经发育的重要因素.
了解产前免疫挑战对学习和记忆等认知功能的影响,对于识别潜在风险和干预至关重要.
神经发育中的性二态性表明,MIA的影响可能在男性和女性后代之间有所不同.

结论:

MIA显著影响后代的神经发育和认知行为,强调产前环境的作用.
免疫反应,基因表达和微质活动的性别特异性差异可能会导致不同的认知结果.
需要进行进一步的研究,以充分阐明MIA对认知的影响背后的复杂,性别特异的机制.

关键词:

学习和记忆的学习和记忆孕产妇的免疫激活产前感染产前感染动物动物性差异性差异性差异性差异性差异性差异性差异性

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Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...