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псилоцибин和慢性神经病痛:一个系统的审查

David S Jevotovsky¹, Harman Chopra², Daniel J Pak³

¹Physical Medicine & Rehabilitation, New York University Grossman School of Medicine, New York, New York, USA.

Regional anesthesia and pain medicine

|August 6, 2024

概括

псилоцибин在缓解慢性疼痛方面表现有前途,但目前的证据质量较低. 需要进一步的高质量研究,使用标准化的协议来确认其作为疼痛管理策略的潜力.

科学领域:

神经科学和药理学神经科学和药理学
疼痛管理研究疼痛管理研究
迷幻研究迷幻研究

背景情况:

慢性疼痛是一个全球性的健康问题,需要新的治疗方法.
一种迷幻化合物psilocybin正在成为慢性疼痛疾病的潜在治疗方法.
尽管它具有治疗潜力,但psilocybin仍然是一个附表I受控物质.

研究的目的:

系统地审查和批判性地评估现有证据,用于治疗慢性疼痛的西宾.
评估psilocybin在缓解慢性疼痛方面的疗效,考虑各种剂量方案和患者的治疗结果.
为了确定目前的研究环境中关于西在缓解疼痛中的作用的差距.

主要方法:

在主要数据库 (PubMed,CINAHL,Web of Science,Cochrane Library,EMBASE) 进行了全面的系统文献搜索,截至2024年1月.
根据预先定义的资格标准,评价Psilocybin用于慢性疼痛管理的研究被纳入.
方法质量使用MASTER尺度进行评估,证据的强度使用GRADE框架进行分级.

主要成果:

确定了28项研究,提供了有关剂量,治疗条件和患者结局的数据.
大多数被纳入的研究 (76.2%) 被评为具有低或非常低的方法质量.
初步发现表明,psilocybin对慢性疼痛有潜在的益处,一些使用0.14 mg/kg剂量的研究显示出有希望的结果,尽管证据的质量整体较低.

结论:

目前的证据表明,psilocybin在治疗慢性疼痛方面可能发挥作用.
由于方法问题和可用的研究质量普遍较低,存在重大限制.
采用标准化方案的进一步严格,高质量的研究对于验证西宾在慢性疼痛治疗中的有效性和安全性至关重要.

关键词:

慢性疼痛是一种慢性疼痛.补充疗法补充疗法补充疗法伦理学在伦理学方面.神经疼痛是一种神经疼痛.疼痛管理疼痛管理

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