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累积氧暴露和症之间的关系:系统性审查和剂量反应元分析

Patrick Howlett¹, Jeffrey Gan², Maia Lesosky²

¹National Heart and Lung Institute, Imperial College London, London, UK p.howlett@imperial.ac.uk.

|August 6, 2024

概括

减少可呼吸晶体二氧化 (RCS) 的暴露,显著降低了病风险,特别是对于矿工来说. 这项研究支持降低英国的暴露限值,以保护工人免受这种慢性肺病的影响.

科学领域:

职业健康职业健康职业健康
肺部医学肺部医学
环境健康环境健康

背景情况:

病是一种严重的肺部疾病,是由于暴露于晶体二氧化.
没有系统性审查将累积的二氧化暴露与病风险联系起来.
英国的二氧化暴露限值正在审查中.

研究的目的:

系统地审查和元分析累积可呼吸晶体二氧化 (RCS) 暴露和病之间的关系.
为英国的曝光限值审查提供信息.

主要方法:

在Web of Science,Medline和Embase的系统文献搜索.
包括有放射性,尸检或死亡证书的研究和>20年的随访.
在不同累积的RCS暴露下计算出病的相对风险 (RR) 和绝对风险降低 (ARR).

主要成果:

包括8项研究 (10个队列,65,977名参与者,8792例).
累积化风险因方法而异,在采矿队伍中较高.
将累计RCS暴露量从4降至2mg/m3年显示,矿工 (RR 0.23) 和非矿工 (RR 0.55) 的风险降低显著.

结论:

这些发现支持将英国RCS的允许暴露极限从0.1 mg/m3降低到0.05 mg/m3.
这种减少对于采矿人口来说尤为重要.
对非采矿人口需要进行更多的研究.

关键词:

临床流行病学临床流行病学职业肺部疾病职业肺部疾病

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