在巴西接种Ad26.COV2·S疫苗后,抗PF4阳性和血小板激活
Joanna Bokel1, Remy Martins-Gonçalves2, Eduarda Grinsztejn3
1Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Vaccine
|August 6, 2024
概括
Ad26.COV2·S COVID-19 疫苗很少引起疫苗诱导的免疫性血栓缺血和血栓形成 (VITT). 这项研究发现,在接种疫苗后,抗PF4抗体的发生频率非常低,以及轻微的血小板缺血.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 血液学 血液学 血液学
背景情况:
- Ad26.COV2·S COVID-19 疫苗很少与疫苗诱导的免疫性血栓缩和血栓形成 (VITT) 有关.
- 在接种疫苗后调查VITT相关标志物的患病率对于疫苗安全监测至关重要.
研究的目的:
- 为了确定Ad26.COV2·S疫苗接种后抗PF4抗体阳性,血小板减少,D-二次体升高和血小板炎症标志物的频率.
- 在接种疫苗后具有实验室异常的个体中评估血小板激活检测.
主要方法:
- 这是一项前性研究,评估了630名参与者在Ad26.COV2·S疫苗接种前和3周后.
- 测量了血小板计数,D-二分体和抗PF4抗体;在病例和对照中评估了血栓炎症标志物和血小板功能测定.
主要成果:
- 观察到低频率 (0.79%) 的血小板缺血和 (1.57%) 阳性抗PF4抗体.
- 在4.91%的参与者中发现了升高的D-二次体;记住了血栓炎症标志物的最小增加.
- 血小板激活试验没有显示与疫苗接种相关的临床显著增加.
结论:
- Ad26.COV2·S疫苗接种与非常低的抗PF4抗体发生率和轻微的血小板缺血有关.
- 疫苗接种后没有检测到血栓炎症或血小板激活的临床相关增加.
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