在初级高血压中使用食酸降低进行脏和心血管保护:为期五年的干预性随机对照试验
Nimrit Goraya1, Nicolaos E Madias2, Jan Simoni3
1Department of Internal Medicine, Baylor Scott and White Health, Temple, Tex; Department of Internal Medicine, Texas A&M Health Sciences Center College of Medicine, Temple.
The American journal of medicine
|August 6, 2024
概括
富含水果和蔬菜的饮食和二碳酸的饮食会降低饮食中的酸性,降低慢性病和心血管疾病的风险. 水果和蔬菜在改善高血压患者的血压和心血管风险方面比二碳酸更有效.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 高水果和蔬菜摄入量与慢性病 (CKD) 和心血管疾病 (CVD) 风险的降低有关.
- 低酸性饮食,包括富含水果和蔬菜或补充二碳酸 (NaHCO3) 的饮食,与改善CKD和CVD结局有关.
- 尽管有这些好处,但水果和蔬菜的消费并不是高血压管理的常见组成部分.
研究的目的:
- 评估水果和蔬菜消费与口服碳酸在治疗高血压方面的有效性.
- 评估这些干预措施对慢性病进展和五年内心血管疾病风险指数的影响.
- 确定水果和蔬菜是否可以作为高血压治疗的基本要素.
主要方法:
- 进行了一项随机试验,涉及153名高血压患者,患有宏蛋白尿症.
- 参与者接受了富含水果和蔬菜的饮食,口服二碳酸 (NaHCO3) 或常规护理.
- 在五年期间,对病进展和心血管疾病风险标志物进行了监测.
主要成果:
- 与常规护理相比,水果/蔬菜和NaHCO3干预措施都减缓了慢性病的进展.
- 摄入水果和蔬菜的患者在缩血压和心血管疾病风险指数上表现出比接受NaHCO3或常规护理的患者更大的改善.
- 这些心血管益处甚至在降低标准CKD和CVD保护药物的剂量时也被观察到.
结论:
- 这项研究支持将水果和蔬菜作为高血压的主要治疗策略.
- 用水果和蔬菜进行饮食干预可以有效地减少慢性病进展和心血管疾病风险.
- 这种方法为管理高血压及其相关并发症提供了一个有希望的基础策略.
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