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Updated: Jun 17, 2025

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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通过SAF312和胆固醇抑制TRPV1的结构基础

Junping Fan1, Han Ke2, Jing Lei3,4

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Organic Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. fanjp@pku.edu.cn.

Nature communications
|August 6, 2024
PubMed
概括

SAF312通过与其化物口袋结合,有效地抑制了短暂受体潜在化物1 (TRPV1) 通道. 这项研究揭示了冷-EM结构,揭示了SAF312和胆固醇如何一起阻止TRPV1疼痛信号的作用.

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