素神经元介导抵抗诱惑的自愿运动
Alexander L Tesmer1, Xinyang Li1, Eva Bracey1
1Neurobehavioural Dynamics Laboratory, Department of Health Sciences and Technology, Eidgenössische Technische Hochschule Zürich, Schwerzenbach, Switzerland.
小鼠更喜欢自愿运动而不是美味的食物,即使两者都可用. 脑下垂体的低素/素神经元 (HONs) 驱动了这种吃-跑仲裁,促进了运动优先级.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 运动科学 运动科学
背景情况:
- 身体活动提供了显著的健康益处,但许多人运动不足.
- 驱动运动优先于其他有价值的活动的潜在神经机制在很大程度上是未知的.
研究的目的:
- 为了研究小鼠喜欢自愿的轮子运行,而不是可口的食物消费的神经基础.
- 了解下丘脑中低素/素神经元 (HONs) 如何调解饮食和运动行为之间的仲裁.
主要方法:
- 开发了一种新的行为任务,允许小鼠在轮子运行和吃美味的食物之间自由交替.
- 利用因果操纵和对食欲和消费行为相关分析.
- 在这个决策过程中检查了下丘脑中低素/素神经元 (HONs) 的作用.
主要成果:
- 鼠标始终选择在轮子上花费大量时间,即使可口的食物是可用的替代品.
- 脑下垂体的低蛋白/素神经元 (HONs) 被确定为关键的神经基质,即为偏好轮子运行提供实例.
- HON操纵对行为的影响取决于背景,当食物和跑步选项都存在时,观察到的最显著的影响.
结论:
- 脑下垂体的低素/素神经元 (HON) 活动在运动和食物之间的选择中起着关键作用.
- HONs促进了吃-跑的仲裁,导致人们更喜欢自愿的体育活动而不是美味的食物消费.
- 这些发现为对激发行为的神经控制和对运动的优先考虑提供了新的见解.
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