心脏康复患者的高尿路血症:患病率和与功能改善和左心室喷射小部分相关
Matteo Fortuna1, Chiara Tognola2, Michela Algeri2
1School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
概括
超尿路血 (HU) 在心脏康复患者中很常见,与较低的射出分数 (EF) 相关,但不是功能改善. 该研究使用了经典和新的HU截止值,发现后者增加了患病率,但没有影响EF关联.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 内部医学 内部医学
背景情况:
- 尿酸 (UA) 和高尿血 (HU) 在心脏康复 (CR) 患者中的作用仍未得到充分研究.
- 了解HU的影响对于优化CR结果至关重要.
研究的目的:
- 为了确定在CR患者中HU的患病率.
- 评估HU与功能改善 (6分钟步行测试) 和左心室喷射率 (EF) 之间的关联.
- 为了比较传统的HU切线与较新的URRAH研究标准.
主要方法:
- 411名因急性或慢性冠状动脉综合征接受CR治疗的患者被纳入.
- 使用经典的 (>7 mg/dL男性,>6 mg/dL女性) 和URRAH (>5.6 mg/dL男性,>5.1 mg/dL女性) 截止值来定义HU.
- 患者在入院和出院时接受了6分钟步行测试和心声回声学.
主要成果:
- 平均UA为5.6±1.4毫克/dL.
- HU的患病率为19.5% (经典切线) 和47.4% (URRAH切线).
- UA和HU (经典切线) 与吸收和放电EF相关,但不是功能性改善. 在URRAH切断时,没有显著的EF相关性.
结论:
- HU在CR患者中普遍存在,与ACS和CCS患者相似.
- 虽然HU (经典切断) 与EF相关,但它不能预测功能恢复.
- URRAH切线识别了更多的HU病例,但在这个队列中缺乏与EF的显著关联.
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