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宇宙是不对称的,小鼠的大脑也是如此

Alejandro Rivera-Olvera¹, Danielle J Houwing^1,2, Jacob Ellegood³

¹Donders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands.

Molecular psychiatry

|August 6, 2024

概括

鼠标大脑不对称性显示出强大的模式,右前侧和左后侧体积较大,与人类不同. 自闭症谱系障碍模型表现出明显的不对称性,表明了物种特异性特征和研究中的小鼠模型的潜力.

科学领域:

神经科学是一个神经科学.
比较解剖学的比较解剖学
神经发育障碍神经发育障碍

背景情况:

半球大脑不对称是人类的一个基本组织原则,与自闭症谱系障碍 (ASD) 等精神疾病有关.
大脑不对称性并不仅限于人类,在其他物种中也可以观察到,包括小鼠.
检测微妙的不对称性模式通常需要大样本大小.

研究的目的:

使用大型数据集,研究小鼠半球大脑不对称性的范围和大小.
与人类相比,识别潜在的特定物种的不对称性模式.
探索自闭症谱系障碍 (ASD) 的遗传模型中的不对称性模式.

主要方法:

利用了来自安大略省神经发育网络2000多只小鼠的结构性MRI数据.
包括与自闭症谱系障碍 (ASD) 相关的遗传模型.
进行集群分析以识别明显的不对称模式.

主要成果:

在小鼠大脑中证明了强大的半球不对称性.
观察到较大的右半球体积在前面和较大的左半球体积在后面,与人类模式形成鲜明对比.
在自闭症谱系障碍 (ASD) 模型中确定了明显的不对称性模式.

结论:

鼠标大脑不对称性表现出强大的,与人类观察到的不同,与物种特定的模式.
自闭症谱系障碍 (ASD) 模型中的明显不对称模式反映了非典型发育人类的发现.
鼠标模型显示了研究典型和非典型大脑不对称性的潜力,但物种之间的差异需要仔细考虑.

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