T1R2 / T1R3多态性影响甜食和脂肪感知:肥胖发展背景下SNP和BMI之间的相关性
Vinithra Ponnusamy1, Gowtham Subramanian1, Keerthana Vasanthakumar1
1Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India.
Human genetics
|August 6, 2024
概括
甜味受体 (T1R2/T1R3) 的遗传变异影响脂肪敏感性和饮食偏好,影响印度成年人的肥胖风险. 这些味觉基因中的多态性与改变的味觉感知和更高的唾液氨酶活性有关.
科学领域:
- 遗传学 是一个遗传学.
- 营养科学 营养科学
- 生理学 生理学 生理学
背景情况:
- 味觉受体的遗传变异与味觉感知和肥胖有关.
- 肥胖与对甜食,高脂肪食物的偏好增加有关.
- 了解味觉受体遗传学对于解决饮食偏好和肥胖至关重要.
研究的目的:
- 评估T1R2/T1R3多态度 (rs35874116,rs307355) 对印度成年人脂肪敏感性的交叉调节.
- 调查味觉敏感性,体重指数 (BMI) 和特定基因多态性 (T1R2,T1R3,CD36) 之间的关联.
- 探索与肥胖有关的遗传变异,味觉和唾液氨酶活性之间的关系.
主要方法:
- 在249名印度成年人中,使用一般标记大小尺度 (gLMS) 评估了对酸 (LA) 和糖的味道敏感性.
- 在T1R2,T1R3和CD36基因中的多态性被使用基于TaqMan探针的RT-PCR确定.
- 用色度测量方法测量了唾液氨酶活性 (3,5-丁酸盐酸).
主要成果:
- 与健康成年人相比,肥胖个体对利诺基酸和糖糖的敏感性较低.
- 较高比例的肥胖个体携带了CD36,T1R2和T1R3多态的特定基因型.
- 在T1R2/T1R3受体中的多态性与甜味和脂肪的感知变化以及更高的唾液氨基酶活性显著相关.
结论:
- 在T1R2/T1R3味觉受体中的遗传变异影响了对甜味和脂肪味道的感知.
- 这些遗传变异可能通过影响饮食偏好,在肥胖的发展中发挥作用.
- 这些发现突出了遗传学,味觉感知和代谢健康之间的复杂相互作用.
相关概念视频
Obesity
418
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
418
Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
Single Nucleotide Polymorphisms-SNPs
14.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.9K
Genome-wide Association Studies-GWAS
13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.3K
Human Genetics
551
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
551
Epistasis
46.6K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
46.6K


