灵活的表面声波技术用于增强通过皮肤递送药物的灵活表面声波技术
Jikai Zhang1, Duygu Bahar1, Hui Ling Ong1
1Faculty of Engineering and Environment, Northumbria University, Newcastle Upon Tyne, Newcastle, NE1 8ST, UK.
Drug delivery and translational research
|August 6, 2024
概括
这项研究引入了一种灵活的表面声波 (SAW) 补丁,用于增强大分子的通过皮肤递送药物. 该SAW贴片成功地通过皮肤替代物传递了宏分子,克服了以前的传递挑战.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 通过皮肤递送药物比口服或注射途径具有优势,提供一致的药物度,避免全身毒性.
- 提高大型水友性分子的皮肤透率仍然是传统和充电式透皮系统面临的重大挑战.
- 现有的充电补丁 (微针,电,热,超声波) 面临着可穿戴设备的集成问题.
研究的目的:
- 开发和评估一款灵活的表面声波 (SAW) 补丁平台,用于通过皮肤输送宏分子.
- 评估SAW技术在通过皮肤替代物传递大分子 (高达2000kDa) 的有效性.
- 阐明SAW增强的巨分子通过皮肤传输的机制.
主要方法:
- 开发一个灵活的表面声波 (SAW) 补丁.
- 使用阿加凝和猪皮肤 (角层) 作为人类皮肤替代品的评估.
- 输送标有fluorescein isothiocyanate的德克斯分子,其大小在4到2000kDa之间.
- 对交付深度的分析和运输机制的识别.
主要成果:
- 在阿加罗斯凝中成功通过皮肤输送2000kDa分子,最大1.1毫米.
- 在猪皮中分别向100微米和25微米的深度输送4-2000kDa分子.
- 确定的机制包括机械动,局部流动,声热效应和潜在的声洞化.
- 增强SAW传输取决于波浪参数,温度和分子量.
结论:
- 灵活的SAW贴片平台有效地促进了大宏分子的通过皮肤输送.
- SAW 技术为克服生物制剂通过皮肤输送的障碍提供了一个有希望的替代方案.
- 进一步优化SAW参数可以增强可穿戴药物输送系统的治疗应用.
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