身体活动和认知:从思考和生活与癌症研究的纵向发现
Ashley L Artese1,2, Xingtao Zhou3, Danielle B Tometich4
1Department of Exercise Science and Health Promotion, Charles E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL, USA.
Journal of the National Cancer Institute
|August 7, 2024
概括
年长的乳腺癌幸存者从事的体力活动较少,报告认知能力较差. 满足有氧指导方针改善了感知认知,强调了在幸存者护理中需要进行运动干预的需要.
科学领域:
- 在瘤学瘤学.
- 老年学是一门学科.
- 运动科学 运动科学
背景情况:
- 身体活动对认知有积极的影响,但其对老年乳腺癌幸存者的认知和炎症的纵向影响尚未得到充分研究.
- 对身体活动,认知和炎症的客观测量提供了对生存挑战的关键见解.
研究的目的:
- 研究与非癌症对照组相比,老年乳腺癌幸存者的客观测量的体力活动,认知功能和炎症之间的纵向关系.
- 为了确定满足体育活动指南是否会影响这一群体感知到的认知功能.
主要方法:
- 一项纵向研究涉及216名老年乳腺癌幸存者和216名年龄相匹配的对照,每年评估长达5年.
- 客观的体力活动是用部穿戴的动态仪测量;认知功能是通过神经心理测试和癌症治疗-认知功能的功能评估 (FACT-Cog) 来评估的.
- 测量了循环炎症标记物 (C-反应蛋白,中白素-6),并使用混合效应和调解模型分析了数据.
主要成果:
- 与对照组相比,乳腺癌幸存者表现出较低的中度至强度体力活动水平,并且不太可能符合有氧活动指南,特别是随着时间的推移.
- 满足有氧体力活动指南与感知认知功能的改善有关 (FACT-Cog得分).
- 较高的体力活动与炎症标志物相反相关,但炎症并没有介导体力活动和感知认知之间的关系.
结论:
- 年长的乳腺癌幸存者在体力活动方面不如他们的非癌症同龄人,活动水平与基线相比进一步下降.
- 遵守有氧体力活动指南与幸存者更好地感知认知功能有关.
- 幸存者护理计划应包括体育活动监测和有针对性的运动干预措施,以增强康复和福祉.
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