在印度重新定义HCC监控:呼吁创新和包容性战略
Amit Yelsangikar1, Prachi S Patil2
1Department of Gastroenterology, Aster CMI Hospital, Bengaluru, India.
Journal of clinical and experimental hepatology
|August 7, 2024
概括
印度肝细胞癌 (HCC) 诊断需要改进超越当前超声波和AFP测试的策略. 像血液标记物和数字技术这样的新方法可以在资源有限的环境中提高早期检测和患者的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 肝细胞癌 (HCC) 是印度癌症死亡的主要原因,发病率正在上升.
- 慢性HBV感染是主要原因,但代谢功能障碍相关的脂肪性肝病 (MASLD) 正在出现.
- 大多数HCC病例的诊断迟到,导致预后不佳和治疗选择有限.
研究的目的:
- 重新评估目前对印度早期HCC的监测和诊断策略.
- 考虑到不断变化的流行病学,探索替代和改进的查方法.
- 为了解决现有方法的局限性,特别是对于MASLD患者.
主要方法:
- 审查目前的印度国家肝脏研究协会 (INASL) 关于HCC监测的指南.
- 六个月一次的超声波 (USG) 和阿尔法胎蛋白 (AFP) 测试的局限性分析.
- 探索国际模型 (例如日本指导方针) 和新兴技术 (例如PIVKA II,GALAD/GAAD分数,数字健康).
主要成果:
- 目前在印度的HCC监测没有很好的组织,并且有很大的局限性,特别是在MASLD.
- 建议转向使用血液标记物和数字技术进行社区查.
- 国际数据表明,新的标记和算法可以改进监控.
结论:
- 印度需要彻底改变HCC查策略.
- 整合先进的标记物,数字健康和潜在的社区方法可以改善早期检测.
- 建立全国性慢性肝病注册和卓越中心对于有效实施和改善患者治疗结果至关重要.
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