与托相关的肠道代谢物,大脑活动和自闭症症状学之间的关系
Lisa Aziz-Zadeh1, Emeran Mayer2, Jennifer Labus3
1USC.
Research square
|August 7, 2024
概括
肠道微生物代谢物,如托的代谢物,与大脑活动差异和自闭症谱系障碍 (ASD) 严重程度有关. 这项研究揭示了这些肠-大脑相互作用如何影响ASD症状和处理.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 理论上,肠道微生物代谢物可以影响自闭症谱系障碍 (ASD) 病理生理学.
- 之前的研究表明,自闭症患者和神经类型 (NT) 对照者之间的肠道微生物群存在差异.
- 在ASD中,人类大脑和肠道微生物群之间的相互作用仍未得到充分探索.
研究的目的:
- 研究肠道微生物代谢物,特别是与托相关的代谢物,与ASD儿童的大脑活动之间的关系.
- 检查这些肠-大脑相互作用如何与ASD严重程度和特定症状相关.
- 确定大脑活动在微生物代谢物和ASD症状之间联系中的潜在调解作用.
主要方法:
- 一项横截面的病例对照观察研究,涉及43名患有自闭症儿童和41名NT儿童 (8-17岁).
- 利用便代谢学,基于任务的功能磁共振成像 (fMRI),专注于社会情感和感官范式,以及行为评估.
- 使用一般线性模型和调度建模来分析数据.
主要成果:
- 便中的特异性托相关代谢物与ASD相关区域 (岛屿,带状) 的非典型大脑活动有关.
- 这些代谢物还与ASD严重程度,厌恶感和感官敏感性相关.
- 中岛和中环状活动调解了微生物代谢产物 (乳酸,酸和贝他因) 与ASD严重程度/厌恶敏感性之间的关系.
结论:
- 这项研究是第一个证明肠道代谢物-大脑活动相互作用如何影响自闭症症状的研究.
- 这些发现突出了托芬代谢在ASD病理生理学中的作用,通过功能性大脑途径参与阴道和感官/情绪处理.
- 表明潜在的肠-大脑轴机制有助于ASD症状.
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