睡眠时间的不规则性和发生心血管疾病的风险在英国生物银行
Tianyi Huang1, Sina Kianersi2, Heming Wang2,3
1Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
medRxiv : the preprint server for health sciences
|August 7, 2024
概括
睡眠时间不规则增加了心血管疾病 (CVD) 的风险. 这种联系在长时间睡眠者中更强烈,并且不受心血管疾病遗传风险的改变.
科学领域:
- 心脏病学 心脏病学
- 睡眠科学 睡眠科学
- 流行病学 流行病学
背景情况:
- 循环节障碍,通过可变的睡眠时间来表明,与心血管疾病 (CVD) 风险有关.
- 心血管疾病类型,平均睡眠时间和遗传倾向对这种联系的影响需要进一步调查.
研究的目的:
- 调查睡眠时间变化与重大心血管事件风险之间的关联.
- 探索这种关联是否因心血管疾病类型 (心肌梗塞,中风) 而有所不同,还是因平均睡眠时间和遗传风险而有所改变.
主要方法:
- 使用7天加速计数据对86,219名英国生物库参与者的前性分析.
- 睡眠不规则,用睡眠时间的标准偏差 (SD) 来量化.
- 通过与健康记录的链接追踪的重大心血管疾病事件 (心肌梗塞,中风).
主要成果:
- 睡眠时间增加1小时SD与心血管疾病 (HR1.19),心肌梗塞 (HR1.23) 和中风 (HR1.17) 的风险增加有关.
- 在调整了各种生活方式和临床因素后,这些关联仍然很重要.
- 睡眠不规则增加了心血管疾病的风险,无论遗传风险如何,但在睡眠时间超过8小时的人中更为明显.
结论:
- 睡眠时间的夜间变化更大,始终与重大心血管事件的风险增加有关.
- 睡眠不规则和心血管疾病风险之间的观察到的关联不受遗传风险的影响,但在长时间睡眠者中更为明显.
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