大脑对超加工奶昔的多巴胺反应是高度可变的,与人类的肥胖没有显著的关系
Valerie L Darcey1,2, Juen Guo1, Meible Chi1
1Integrative Physiology Section, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
medRxiv : the preprint server for health sciences
|August 7, 2024
概括
超加工食品,如含糖的奶昔,不会在大脑中引发显著的多巴胺释放.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 成研究 研究成研究
背景情况:
- 超加工食品 (UPF) 通常含有高脂肪和高糖.
- 假设这些食物会导致上,因为它们有可能引起大脑过度多巴胺反应,类似于滥用药物.
- 这种多巴胺反应被认为发生在摄入后 (消化后).
研究的目的:
- 为了研究对超加工食品的脑后刺激性多巴胺反应.
- 为了将这种反应与通常在成性物质中看到的多巴胺反应进行比较.
- 检查这种反应与身体质量指数 (BMI) 之间的关系.
主要方法:
- 使用[11C]拉克洛普里德正子发射断层扫描 (PET) 来测量多巴胺释放.
- 在饮用超加工牛奶后,测量了后静脉条性多巴胺反应.
- 招募了50名健康的年轻成年人,他们的BMI范围广泛 (20-45kg/m2).
主要成果:
- 在牛奶消费后,在条纹体 (p=0.62) 或其子区域 (p>0.33) 中没有检测到显著的后期兴奋性多巴胺反应.
- 个体多巴胺反应显示出很高的变化.
- 反应与脂肪度没有显著相关 (BMI:r=0.076,p=0.51;身体脂肪:r=0.16,p=0.28).
结论:
- 对超加工牛奶的后刺激性多巴胺反应可能比许多成药物要小得多.
- 标准的PET方法可能没有足够的灵敏度来检测多巴胺对这些食物的反应.
- 通过夸大多巴胺释放的UPFs的假设上机制可能不适用于所有此类产品.
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