一个长时间持久的三氨载微针贴片,用于长时间的皮肤输送
Nasrin Zarei Chamgordani1, Sasan Asiaei2, Fatemeh Ghorbani-Bidkorpeh1
1Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iranian journal of pharmaceutical research : IJPR
|August 7, 2024
概括
这项研究开发了聚乳酸微针,用于长时间输送triamcinolone乙化物 (TrA),为痕治疗和伤口关闭提供了一种新方法. 微针证明了有效的药物释放和穿透皮肤.
科学领域:
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
- 药物输送系统 药物输送系统
背景情况:
- 伤口或烧伤造成的痕是美学上不理想的皮肤病变.
- 传统的三氨治疗需要频繁的应用,以治愈痕.
- 微针技术为长时间的皮肤药物递送和伤口关闭提供了潜力.
研究的目的:
- 开发一种聚乳酸 (PLA) 微针贴片,用于持续释放三氨酸 (TrA).
- 评估这些微针在伤口边缘关闭和痕预防/治疗方面的潜力.
主要方法:
- 通过微型成型溶剂造制造3%和10%的TrA装载的PLA微针.
- 使用光学显微镜,XRD,FT-IR和DSC进行表征.
- 评估机械强度,在人体皮肤中的插入深度,在34天内体外释放动力学和ex vivo皮肤透.
主要成果:
- 统一的PLA微针成功制造,没有结构缺陷.
- 在TrA和PLA之间没有观察到化学相互作用或热/晶度变化.
- 微针达到900-1000微米的透深度,在Higuchi和零级动力学后持续释放34天.
结论:
- 装有TrA的PLA微针可以使用溶剂造方法有效地制造.
- 这些微针具有合适的机械性能和延长药物释放概况.
- 开发的微针贴片显示了改善痕治疗和伤口管理的前景.
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